Alternate Name	Melanoma-derived growth regulatory protein precursor, Cartilage-derived retinoic acid-sensitive protein, CD-RAP, MIA, Melanoma inhibitory activity protein
Gene Symbol	MIA
Gene ID	8190
Accession #	Q16674
Source	E. coli
Appearance	Lyophilized protein
Physical Form Description	Sterile filtered and lyophilized with no additives
Molecular Weight	12.2 kDa
Purity by SDS-PAGE	≥98%
Purity by	≥98%
Endotoxin Level	<0.1>
Biological Activity	The biological activity is determined by the inhibitory effect on the invasion of Mel In Tumor cells and found active in Mel In assay.
Reconstitution Instructions	Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers
Handling	Centrifuge the vial prior to opening.
Storage Conditions	-20°C
USAGE	For Research Use Only! Not to be used in humans

Description:

MIA is the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family; MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells that promotes melanoma metastasis by binding competitively to fibronectin and laminin in a manner that results in melanoma cell detachment from the extraCellular matrix in vivo. Elevated levels of MIA may represent a clinically useful marker for diagnosis of melanoma metastasis as well as a potential marker for rheumatoid arthritis. Recombinant human MIA is a 12.2 kDa globular protein containing 108 amino acid residues including two intramolecular disulfide bonds.

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